The use of hypermedia as an instructional resource in teaching and learning has led to new opportunities for student to explore and construct their learning, However, despite the benefits derived from hypermedia instructional resources, traditional teaching methods dominated academic institutions in Nigeria. The current study explores the determinants that predict the actual use of hypermedia instructional resources for the teaching of Digital electronics courses in Nigerian universities, the study adopted an explanatory sequential mixed method research design, Survey research is conducted on 120 electrical and electronics technology education undergraduates’ students. Structural equation modeling using Smart PLS-SEM software was performed to evaluate the proposed hypotheses, while a semi-structured interview was conducted and analyzed through the inherent future of Nvivo11 to support the quantitative data. The results revealed that Perceived Ease of Use and Readiness were found to be significant predictors of the actual use of hypermedia instructional resources for the teaching of digital electronic courses. This paper recommended that educational technology practitioners and University management consider Perceived Ease of Use and Readiness as factors that predict the actual use of Hypermedia Instructional Resources in the teaching of digital electronics courses in Nigerian universities before financing the development of Hypermedia Instructional Resources for teaching and learning.