Knowledge is one of the basic aspects of scientific literacy. For targeted enhancement of scientific literacy it is necessary to diversify the methodical activities. The results of the research indicate on the necessity to enhance the formation of scientific literacy in chemistry lessons by motivating students to think about the nature as unified system. Based on the results of a pedagogic research the new teaching and learning method was developed, called the TETRA- method. The tetrahedral spatial mind model is used for the application of this method which is based on the fact that our environment is dimensional. The actions of the model are oriented to discovery and understand various thematic interconnections which form connected knowledge. The results obtained in the approbation of the method indicate that during chemistry lessons students showed greater interest, concurrently the level of students' knowledge level raises up. The obtained students' knowledge which is based on understanding enhances activation of the students’ cognitive processes. By the developing such students’ competences which are creating scientific literacy is important to show meaning of knowledge in chemistry influence on the environment and society.